| Welcome to Lake City, South CarolinaLake City is located in the eastern section of the South Carolina in Florence County. Our city is the center of a thriving agricultural area, well known for tobacco farming and diversified industries. It is located at the junction of US Highway 378 and US Highway 52. Lake City is located 23 miles from Florence, 78 miles from Columbia, 63 to Myrtle Beach and 8 |
